Anti-Recombinant-Phospho-TAOK1/2/3-S181 + S181 + S177 antibody [RM2M45] (STJA0026108)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Phospho-TAOK1/2/3-S181 + S181 + S177 for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2M45 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | TAOK1TAOK357551513479344TAOK1_HUMANTAOK3_HUMANTAOK2_HUMAN |
Additional Info
| Post Translational Modifications | Proteolytically processed by caspase-3 (CASP3). Autophosphorylated. Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2. |
| Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system. Also plays a role in the regulation of neuronal migration to the cortical plate. |
| Protein Name | Serine/Threonine-Protein Kinase Tao1Kinase From Chicken Homolog BHkfc-BMark KinaseMarkkProstate-Derived Sterile 20-Like Kinase 2Psk-2Psk2Prostate-Derived Ste20-Like Kinase 2Thousand And One Amino Acid Protein Kinase 1Taok1Htaok1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tao1 antibodyAnti-Kinase From Chicken Homolog B antibodyAnti-Hkfc-B antibodyAnti-Mark Kinase antibodyAnti-Markk antibodyAnti-Prostate-Derived Sterile 20-Like Kinase 2 antibodyAnti-Psk-2 antibodyAnti-Psk2 antibodyAnti-Prostate-Derived Ste20-Like Kinase 2 antibodyAnti-Thousand And One Amino Acid Protein Kinase 1 antibodyAnti-Taok1 antibodyAnti-Htaok1 antibodyAnti-TAOK1 antibodyAnti-KIAA1361 antibodyAnti-MAP3K16 antibodyAnti-MARKK antibody |
Information sourced from Uniprot.org