| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4945RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDE10A |
| Gene ID: | 10846 |
| Uniprot ID: | PDE10_HUMAN |
| Immunogen Region: | 439-779 aa |
| Immunogen Sequence: | SICTSEEWQGLMQFTLPVRL CKEIELFHFDIGPFENMWPG IFVYMVHRSCGTSCFELEKL CRFIMSVKKNYRRVPYHNWK HAVTVAHCMYAILQNNHTLF TDLERKGLLIACLCHDLDHR GFSNSYLQKFDHPLAALYST STMEQHHFSQTVSILQLEGH NIFSTLSSSEYEQVLEIIRK AIIATDLALYFGNRKQLEEM YQTGSLNLNNQSHRDRVIGL MMTACDLCSVTKLWPVTKL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 439-779 of human PDE10A. (NP_006652.1). |
| Tissue Specificity | Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum. |
| Post Translational Modifications | Isoform PDE10A2: Phosphorylated on Thr-16. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. |
| Protein Name | Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a antibodyAnti-PDE10A antibody |
Information sourced from Uniprot.org
