• Western blot analysis of various lysates, using PDE10A antibody (STJ11104945) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
  • Western blot analysis of various lysates, using BRD9 antibody at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-Recombinant-PDE10A antibody (439-779 aa) [S4945RM] (STJ11104945)

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STJ11104945

£129.50 - £574.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Monoclonal
Clone ID: S4945RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PDE10A
Gene ID: 10846
Uniprot ID: PDE10_HUMAN
Immunogen Region: 439-779 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 439-779 of human PDE10A. (NP_006652.1).
Immunogen Sequence: SICTSEEWQGLMQFTLPVRL CKEIELFHFDIGPFENMWPG IFVYMVHRSCGTSCFELEKL CRFIMSVKKNYRRVPYHNWK HAVTVAHCMYAILQNNHTLF TDLERKGLLIACLCHDLDHR GFSNSYLQKFDHPLAALYST STMEQHHFSQTVSILQLEGH NIFSTLSSSEYEQVLEIIRK AIIATDLALYFGNRKQLEEM YQTGSLNLNNQSHRDRVIGL MMTACDLCSVTKLWPVTKL
Tissue Specificity Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Post Translational Modifications Isoform PDE10A2: Phosphorylated on Thr-16.
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Protein Name Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-418555
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a antibody
Anti-PDE10A antibody

Information sourced from Uniprot.org

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