Anti-Recombinant-PCGF6 antibody [RM2T11] (STJA0026668)

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STJA0026668
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: IF/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-PCGF6 is suitable for use in Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2T11
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: Pcgf6
Gene ID: 71041
Uniprot ID: PCGF6_MOUSE
Post Translational Modifications Phosphorylated during mitosis.
Function Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Protein Name Polycomb Group Ring Finger Protein 6
Mel18 And Bmi1-Like Ring Finger
Ring Finger Protein 134
Database Links Reactome: R-MMU-8953750
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Polycomb Group Ring Finger Protein 6 antibody
Anti-Mel18 And Bmi1-Like Ring Finger antibody
Anti-Ring Finger Protein 134 antibody
Anti-Pcgf6 antibody
Anti-Mblr antibody
Anti-Rnf134 antibody

Information sourced from Uniprot.org

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