Anti-Recombinant-PAWR antibody [RM2T02] (STJA0026659)

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STJA0026659
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Host: Rabbit
Applications: IP/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Prkc Apoptosis Wt1 Regulator Protein is suitable for use in Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2T02
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: PAWR
Gene ID: 5074
Uniprot ID: PAWR_HUMAN
Post Translational Modifications Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
Function Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Protein Name Prkc Apoptosis Wt1 Regulator Protein
Prostate Apoptosis Response 4 Protein
Par-4
Cellular Localisation Cytoplasm
Nucleus
Mainly Cytoplasmic In Absence Of Apoptosis Signal And In Normal Cells
Nuclear In Most Cancer Cell Lines
Nuclear Entry Seems To Be Essential But Not Sufficient For Apoptosis
Nuclear Localization Includes Nucleoplasm And Pml Nuclear Bodies
Alternative Antibody Names Anti-Prkc Apoptosis Wt1 Regulator Protein antibody
Anti-Prostate Apoptosis Response 4 Protein antibody
Anti-Par-4 antibody
Anti-PAWR antibody
Anti-PAR4 antibody

Information sourced from Uniprot.org