Anti-Recombinant-P4HTM antibody [RM2RM70] (STJA0026529)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Transmembrane Prolyl 4-Hydroxylase for use in FC, IHC, IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2RM70 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | P4HTM |
| Gene ID | 54681 |
| Uniprot ID | P4HTM_HUMAN |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Protein Name | Transmembrane Prolyl 4-HydroxylaseP4h-TmHypoxia-Inducible Factor Prolyl Hydroxylase 4Hif-Ph4Hif-Prolyl Hydroxylase 4Hph-4 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Transmembrane Prolyl 4-Hydroxylase antibodyAnti-P4h-Tm antibodyAnti-Hypoxia-Inducible Factor Prolyl Hydroxylase 4 antibodyAnti-Hif-Ph4 antibodyAnti-Hif-Prolyl Hydroxylase 4 antibodyAnti-Hph-4 antibodyAnti-P4HTM antibodyAnti-PH4 antibody |
Information sourced from Uniprot.org