Anti-Recombinant-OGA antibody [RM1E63] (STJA0023057)

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STJA0023057
£309.50 - £472.50
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Host: Rabbit
Applications: IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Protein O-Glcnacase is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1E63
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IHC: 1:100-1:200
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: OGA
Gene ID: 10724
Uniprot ID: OGA_HUMAN
Post Translational Modifications Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other.cleavage does not decrease enzyme activity.
Function Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity. Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
Protein Name Protein O-Glcnacase
Oga
Beta-N-Acetylglucosaminidase
Beta-N-Acetylhexosaminidase
Beta-Hexosaminidase
Meningioma-Expressed Antigen 5
N-Acetyl-Beta-D-Glucosaminidase
N-Acetyl-Beta-Glucosaminidase
Nuclear Cytoplasmic O-Glcnacase And Acetyltransferase
Ncoat
Cellular Localisation Isoform 3: Nucleus
Isoform 1: Cytoplasm
Alternative Antibody Names Anti-Protein O-Glcnacase antibody
Anti-Oga antibody
Anti-Beta-N-Acetylglucosaminidase antibody
Anti-Beta-N-Acetylhexosaminidase antibody
Anti-Beta-Hexosaminidase antibody
Anti-Meningioma-Expressed Antigen 5 antibody
Anti-N-Acetyl-Beta-D-Glucosaminidase antibody
Anti-N-Acetyl-Beta-Glucosaminidase antibody
Anti-Nuclear Cytoplasmic O-Glcnacase And Acetyltransferase antibody
Anti-Ncoat antibody
Anti-OGA antibody
Anti-HEXC antibody
Anti-KIAA0679 antibody
Anti-MEA5 antibody
Anti-MGEA5 antibody

Information sourced from Uniprot.org