Anti-Recombinant-OCLN antibody [RM2H25] (STJA0025692)

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STJA0025692
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: FC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Occludin is suitable for use in Flow Cytometry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2H25
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100, IP: 1:20-1:50, WB: 1:1000-1:5000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: OCLN
Gene ID: 100506658
Uniprot ID: OCLN_HUMAN
Post Translational Modifications Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1. (Microbial infection) Cleaved by S.pyogenes SpeB protease.leading to its degradation. Degradation by SpeB promotes bacterial translocation across the host epithelial barrier.
Function May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes.
Protein Name Occludin
Database Links Reactome: R-HSA-351906
Reactome: R-HSA-8935964
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Junction
Tight Junction
Alternative Antibody Names Anti-Occludin antibody
Anti-OCLN antibody

Information sourced from Uniprot.org

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