Anti-Recombinant-Nav1.1 Na+ channel antibody (C-Term) [K74/71] {FL550 Ex: 550 nm, Em: 575 nm} (STJA0040400)
SPECIFICATIONS
ClonalityMonoclonal
HostChicken
ConjugationFL550 Ex: 550 nm, Em: 575 nm
IsotypeIgY
ImmunogenFusion protein amino acids 1929-2009 (cytoplasmic C-terminus) of rat Nav1.1 (accession number P04774) produced recombinantly in E. Coli
General Information
| Short Description | Chicken monoclonal anti-Recombinant-Nav1.1 Na+ channel (C-Term) for use in ICC and IHC in Human, Mouse, Non-Human Primates and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC |
| Host | Chicken |
| Reactivity | Human/Mouse/Non-Human Primates/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | K74/71 |
| Isotype | IgY |
| Conjugation | FL550 Ex: 550 nm, Em: 575 nm |
| Concentration | 0.5 mg/mL |
| Purification | Purified by affinity chromatography |
| Formulation | 1X PBS, 0.05% Sodium Azide pH 7.4 |
| Storage Instruction | Aliquot and store at ≤-20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap. |
Target Information
| Gene Symbol | Scn1a |
| Gene ID | 81574 |
| Uniprot ID | SCN1A_RAT |
| Immunogen | Fusion protein amino acids 1929-2009 (cytoplasmic C-terminus) of rat Nav1.1 (accession number P04774) produced recombinantly in E. Coli |
| Immunogen Region | C-Term |
| Immunogen Sequence | Rat |
| Specificity | No cross-reactivity with Nav1.2, Nav1.3 and Nav1.10 |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-1516 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. |
| Function | Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits. Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain. |
| Protein Name | Sodium Channel Protein Type 1 Subunit AlphaSodium Channel Protein Brain I Subunit AlphaSodium Channel Protein Type I Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.1 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 1 Subunit Alpha antibodyAnti-Sodium Channel Protein Brain I Subunit Alpha antibodyAnti-Sodium Channel Protein Type I Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.1 antibodyAnti-Scn1a antibody |
Information sourced from Uniprot.org