| Function | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines. Acts as a restriction factor against some viruses: restricts viral replication by binding to mRNA viruses and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates. |
| Protein Name | Nedd4-Binding Protein 1N4bp1 |
| Database Links | Reactome: R-MMU-9758274 |
| Cellular Localisation | CytoplasmCytosolNucleusNucleolusPml BodyPrimarily Localizes To The NucleolusAlso Localizes To The Pml Nuclear BodiesWhen Desumoylated |
| Alternative Antibody Names | Anti-Nedd4-Binding Protein 1 antibodyAnti-N4bp1 antibodyAnti-N4bp1 antibodyAnti-Kiaa0615 antibody |
Information sourced from Uniprot.org
