Anti-Recombinant-MVP antibody [RM2F75] (STJA0025544)

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STJA0025544
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Major Vault Protein is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2F75
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IHC: 1:100-1:200, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: MVP
Gene ID: 9961
Uniprot ID: MVP_HUMAN
Post Translational Modifications Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11.
Function Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Protein Name Major Vault Protein
Mvp
Lung Resistance-Related Protein
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Nucleus
Nuclear Pore Complex
Perinuclear Region
5% Found In The Nuclear Pore Complex
Translocates From The Nucleus To The Cytoplasm Upon Egf Treatment
Alternative Antibody Names Anti-Major Vault Protein antibody
Anti-Mvp antibody
Anti-Lung Resistance-Related Protein antibody
Anti-MVP antibody
Anti-LRP antibody

Information sourced from Uniprot.org

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