| Host: | Rabbit |
| Applications: | IF/IHC/IP/WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 is suitable for use in Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM1V32 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | IF: 1:50-1:200 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | MAP2K2 |
| Gene ID: | 5605 |
| Uniprot ID: | MP2K2_HUMAN |
| Function | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner.by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 2Map Kinase Kinase 2Mapkk 2Erk Activator Kinase 2Mapk/Erk Kinase 2Mek 2 |
| Database Links | Reactome: R-HSA-112411Reactome: R-HSA-170968Reactome: R-HSA-445144Reactome: R-HSA-5210891Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5674499Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9652169Reactome: R-HSA-9656223 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinMembrane Localization Is Probably Regulated By Its Interaction With Ksr1 |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 antibodyAnti-Map Kinase Kinase 2 antibodyAnti-Mapkk 2 antibodyAnti-Erk Activator Kinase 2 antibodyAnti-Mapk/Erk Kinase 2 antibodyAnti-Mek 2 antibodyAnti-MAP2K2 antibodyAnti-MEK2 antibodyAnti-MKK2 antibodyAnti-PRKMK2 antibody |
Information sourced from Uniprot.org