Anti-Recombinant-MADD antibody [RM2RM77] (STJA0026536)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Map Kinase-Activating Death Domain Protein for use in IF, IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2RM77 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | MADD |
| Gene ID | 8567 |
| Uniprot ID | MADD_HUMAN |
Additional Info
| Function | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis. |
| Protein Name | Map Kinase-Activating Death Domain ProteinDifferentially Expressed In Normal And Neoplastic CellsInsulinoma Glucagonoma Clone 20Rab3 Gdp/Gtp Exchange FactorRabgefRab3 Gdp/Gtp Exchange ProteinRab3gep |
| Database Links | Reactome: R-HSA-5357905Reactome: R-HSA-8876198 Q8WXG6-3 |
| Cellular Localisation | Cell MembraneCytoplasmCell ProjectionAxon |
| Alternative Antibody Names | Anti-Map Kinase-Activating Death Domain Protein antibodyAnti-Differentially Expressed In Normal And Neoplastic Cells antibodyAnti-Insulinoma Glucagonoma Clone 20 antibodyAnti-Rab3 Gdp/Gtp Exchange Factor antibodyAnti-Rabgef antibodyAnti-Rab3 Gdp/Gtp Exchange Protein antibodyAnti-Rab3gep antibodyAnti-MADD antibodyAnti-DENN antibodyAnti-IG20 antibodyAnti-KIAA0358 antibody |
Information sourced from Uniprot.org