| Function | Exhibits acyltransferase activity. Exhibits acetyltransferase activity. Activity is calcium-independent. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size. |
| Protein Name | Lysophosphatidylcholine Acyltransferase 1Lpc Acyltransferase 1Lpcat-1Lysopc Acyltransferase 11-Acylglycerol-3-Phosphate O-Acyltransferase1-Acylglycerophosphocholine O-Acyltransferase1-Alkenylglycerophosphocholine O-Acyltransferase1-Alkylglycerophosphocholine O-AcetyltransferaseAcetyl-Coa -Lyso-Platelet-Activating Factor AcetyltransferaseAcetyl-Coa -Lyso-Paf AcetyltransferaseLyso-Paf AcetyltransferaseLysopafatAcyltransferase-Like 2Phosphonoformate Immuno-Associated Protein 3 |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482925Reactome: R-HSA-1483166Reactome: R-HSA-1483191Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneCell MembraneLipid DropletMay Adopt A Monotopic Topology When Embedded In The Lipid Monolayer Of The Lipid DropletWith Both Termini Exposed To The Cytoplasm |
| Alternative Antibody Names | Anti-Lysophosphatidylcholine Acyltransferase 1 antibodyAnti-Lpc Acyltransferase 1 antibodyAnti-Lpcat-1 antibodyAnti-Lysopc Acyltransferase 1 antibodyAnti-1-Acylglycerol-3-Phosphate O-Acyltransferase antibodyAnti-1-Acylglycerophosphocholine O-Acyltransferase antibodyAnti-1-Alkenylglycerophosphocholine O-Acyltransferase antibodyAnti-1-Alkylglycerophosphocholine O-Acetyltransferase antibodyAnti-Acetyl-Coa -Lyso-Platelet-Activating Factor Acetyltransferase antibodyAnti-Acetyl-Coa -Lyso-Paf Acetyltransferase antibodyAnti-Lyso-Paf Acetyltransferase antibodyAnti-Lysopafat antibodyAnti-Acyltransferase-Like 2 antibodyAnti-Phosphonoformate Immuno-Associated Protein 3 antibodyAnti-LPCAT1 antibodyAnti-AYTL2 antibodyAnti-PFAAP3 antibody |
Information sourced from Uniprot.org
