Anti-Recombinant-IRF4 antibody [RM2G21] (STJA0025589)

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STJA0025589
€386.88 - €590.63
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Host: Rabbit
Applications: IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Interferon Regulatory Factor 4 is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2G21
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: IRF4
Gene ID: 3662
Uniprot ID: IRF4_HUMAN
Post Translational Modifications Phosphorylation by ROCK2 regulates IL-17 and IL-21 production.
Function Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.
Protein Name Interferon Regulatory Factor 4
Irf-4
Lymphocyte-Specific Interferon Regulatory Factor
Lsirf
Multiple Myeloma Oncogene 1
Nf-Em5
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Reactome: R-HSA-909733
Reactome: R-HSA-9725371
Reactome: R-HSA-9824585
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Interferon Regulatory Factor 4 antibody
Anti-Irf-4 antibody
Anti-Lymphocyte-Specific Interferon Regulatory Factor antibody
Anti-Lsirf antibody
Anti-Multiple Myeloma Oncogene 1 antibody
Anti-Nf-Em5 antibody
Anti-IRF4 antibody
Anti-MUM1 antibody

Information sourced from Uniprot.org