| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IRF4 (180-451) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IRF4 |
| Gene ID: |
3662 |
| Uniprot ID: |
IRF4_HUMAN |
| Immunogen Region: |
180-451 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-451 of human IRF4 (NP_002451.2). |
| Immunogen Sequence: |
DYVPDQPHPEIPYQCPMTFG PRGHHWQGPACENGCQVTGT FYACAPPESQAPGVPTEPSI RSAEALAFSDCRLHICLYYR EILVKELTTSSPEGCRISHG HTYDASNLDQVLFPYPEDNG QRKNIEKLLSHLERGVVLWM APDGLYAKRLCQSRIYWDGP LALCNDRPNKLERDQTCKLF DTQQFLSELQAFAHHGRSLP RFQVTLCFGEEFPDPQRQRK LITAHVEPLLARQLYYFAQ |
| Tissue Specificity | Lymphoid cells. |
| Post Translational Modifications | Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. |
| Function | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. |
| Protein Name | Interferon Regulatory Factor 4Irf-4Lymphocyte-Specific Interferon Regulatory FactorLsirfMultiple Myeloma Oncogene 1Nf-Em5 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 4 antibodyAnti-Irf-4 antibodyAnti-Lymphocyte-Specific Interferon Regulatory Factor antibodyAnti-Lsirf antibodyAnti-Multiple Myeloma Oncogene 1 antibodyAnti-Nf-Em5 antibodyAnti-IRF4 antibodyAnti-MUM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
