Anti-Recombinant-Glucagon antibody [SM0558] (STJA0010558)

SKU:
STJA0010558

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Host: Mouse
Applications: IHC/IF
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Recombinant-Glucagon is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: SM0558
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol.
Purification: Affinity purification
Dilution Range: IHC/IF (H, R) 1:500-1:1000
Storage Instruction: Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.
Gene Symbol: Gcg
Uniprot ID: GLUC_RAT
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Glucagon
Post Translational Modifications Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function Glucagon: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon-like peptide 1: Potent stimulator of glucose-dependent insulin release (Probable). Also stimulates insulin release in response to IL6. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). Glucagon-like peptide 2: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Glicentin: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. Oxyntomodulin significantly reduces food intake.
Protein Name Pro-Glucagon Cleaved Into - Glicentin - Glicentin-Related Polypeptide
Grpp - Oxyntomodulin
Oxm
Oxy - Glucagon - Glucagon-Like Peptide 1
Glp-1 - Glucagon-Like Peptide 1(7-37
Glp-1(7-37 - Glucagon-Like Peptide 1(7-36
Glp-1(7-36 - Glucagon-Like Peptide 2
Glp-2
Cellular Localisation Secreted
Glucagon-Like Peptide 1: Secreted
Alternative Antibody Names Anti-Pro-Glucagon Cleaved Into - Glicentin - Glicentin-Related Polypeptide antibody
Anti-Grpp - Oxyntomodulin antibody
Anti-Oxm antibody
Anti-Oxy - Glucagon - Glucagon-Like Peptide 1 antibody
Anti-Glp-1 - Glucagon-Like Peptide 1(7-37 antibody
Anti-Glp-1(7-37 - Glucagon-Like Peptide 1(7-36 antibody
Anti-Glp-1(7-36 - Glucagon-Like Peptide 2 antibody
Anti-Glp-2 antibody
Anti-Gcg antibody

Information sourced from Uniprot.org

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