Anti-Recombinant-ENSA antibody [RM1E33] (STJA0023027)

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STJA0023027
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Short Description :Rabbit monoclonal anti-Recombinant-Alpha-Endosulfine for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :RM1E33
Isotype:IgG
Conjugation:Unconjugated
Purification:Protein A/G purified from cell culture supernatant
Dilution Range:WB: 1:500-1:1000
Formulation:0.01M PBS
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol:ENSA
Gene ID:2029
Uniprot ID:ENSA_HUMAN
Post Translational Modifications Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA.
Function Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Protein Name Alpha-Endosulfine
Arpp-19e
Database Links Reactome: R-HSA-2465910
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Alpha-Endosulfine antibody
Anti-Arpp-19e antibody
Anti-ENSA antibody

Information sourced from Uniprot.org

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