Anti-Recombinant-DOK1 antibody [RM2RM24] (STJA0026483)

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STJA0026483
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: IF/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Docking Protein 1 is suitable for use in Immunofluorescence and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2RM24
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: DOK1
Gene ID: 1796
Uniprot ID: DOK1_HUMAN
Post Translational Modifications Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated by LYN. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Protein Name Docking Protein 1
Downstream Of Tyrosine Kinase 1
P62(Dok
Pp62
Database Links Reactome: R-HSA-8849469
Reactome: R-HSA-8853659
Cellular Localisation Isoform 1: Cytoplasm
Nucleus
Isoform 3: Cytoplasm
Perinuclear Region
Alternative Antibody Names Anti-Docking Protein 1 antibody
Anti-Downstream Of Tyrosine Kinase 1 antibody
Anti-P62(Dok antibody
Anti-Pp62 antibody
Anti-DOK1 antibody

Information sourced from Uniprot.org

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