Anti-Recombinant-DBP/GC antibody [RM1J16] (STJA0023406)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Vitamin D-Binding Protein for use in IF and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1J16 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | GC |
| Gene ID | 2638 |
| Uniprot ID | VTDB_HUMAN |
Additional Info
| Post Translational Modifications | Allele GC*1S is O-glycosylated at Thr-436. The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated. The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated. |
| Function | Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. |
| Protein Name | Vitamin D-Binding ProteinDbpVdbGc Protein-Derived Macrophage Activating FactorGc-MafGcmafGc-GlobulinGroup-Specific ComponentGcVitamin D-Binding Protein-Macrophage Activating FactorDbp-Maf |
| Database Links | Reactome: R-HSA-196791 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vitamin D-Binding Protein antibodyAnti-Dbp antibodyAnti-Vdb antibodyAnti-Gc Protein-Derived Macrophage Activating Factor antibodyAnti-Gc-Maf antibodyAnti-Gcmaf antibodyAnti-Gc-Globulin antibodyAnti-Group-Specific Component antibodyAnti-Gc antibodyAnti-Vitamin D-Binding Protein-Macrophage Activating Factor antibodyAnti-Dbp-Maf antibodyAnti-GC antibody |
Information sourced from Uniprot.org