| Host: | 293F Cells |
| Applications: | ELISA/FC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | 293f Cells monoclonal anti-Recombinant-chimeric-Cd48 antigen-Nb-Fc for use in ELISA and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Formulation: | Phosphate-buffered solution |
| Purification: | Recombinant Expression and Affinity purified |
| Concentration: | Lot specific |
| Dilution Range: | ELISA 1:5000-100000FC 1-2 Mu g/Test |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD48 |
| Gene ID: | 962 |
| Uniprot ID: | CD48_HUMAN |
| Specificity: | This recombinant monoclonal antibody can detects endogenous levels of CD5 protein. |
| Immunogen: | Purified recombinant Human CD5 |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenB-Lymphocyte Activation Marker Blast-1Bcm1 Surface AntigenLeukocyte Antigen Mem-102Slam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Tct.1Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibodyAnti-B-Lymphocyte Activation Marker Blast-1 antibodyAnti-Bcm1 Surface Antigen antibodyAnti-Leukocyte Antigen Mem-102 antibodyAnti-Slam Family Member 2 antibodyAnti-Slamf2 antibodyAnti-Signaling Lymphocytic Activation Molecule 2 antibodyAnti-Tct.1 antibodyAnti-Cd Antigen Cd48 antibodyAnti-CD48 antibodyAnti-BCM1 antibodyAnti-BLAST1 antibody |
Information sourced from Uniprot.org