Anti-Recombinant-chimeric-CD166-Nb-Fc antibody (STJA0038597)
SPECIFICATIONS
ClonalityMonoclonal
Host293F Cells
ConjugationUnconjugated
ImmunogenPurified recombinant Human CD45
General Information
| Short Description | 293f Cells monoclonal anti-Recombinant-chimeric-Cd166 antigen-Nb-Fc for use in ELISA and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | 293F Cells |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Recombinant Expression and Affinity purified |
| Dilution Range | ELISA 1:5000-100000FC 1-2 Mu g/Test |
| Formulation | Phosphate-buffered solution |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALCAM |
| Gene ID | 214 |
| Uniprot ID | CD166_HUMAN |
| Immunogen | Purified recombinant Human CD45 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD45 protein. |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6. Contributes to the formation and maturation of the immunological synapse via its interactions with CD6. Mediates homotypic interactions with cells that express ALCAM. Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation. Required for normal hematopoietic stem cell engraftment in the bone marrow. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis.required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation. Promotes neurite extension, axon growth and axon guidance.axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons. Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. |
| Protein Name | Cd166 AntigenActivated Leukocyte Cell Adhesion MoleculeCd Antigen Cd166 |
| Database Links | Reactome: R-HSA-373760 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonDendriteDetected At The Immunological SynapseIEAt The Contact Zone Between Antigen-Presenting Dendritic Cells And T-CellsColocalizes With Cd6 And The Tcr/Cd3 Complex At The Immunological SynapseIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Cd166 Antigen antibodyAnti-Activated Leukocyte Cell Adhesion Molecule antibodyAnti-Cd Antigen Cd166 antibodyAnti-ALCAM antibodyAnti-MEMD antibody |
Information sourced from Uniprot.org