Anti-Recombinant-CHD1L antibody [RM2Q36] (STJA0026396)

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STJA0026396
€360.60 - €549.00
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Short Description :Rabbit monoclonal anti-Recombinant-Chromodomain-Helicase-Dna-Binding Protein 1-Like for use in FC, IF, IHC, IP and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC/IF/IHC/IP/WB
Host:Rabbit
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :RM2Q36
Isotype:IgG
Conjugation:Unconjugated
Purification:Protein A/G purified from cell culture supernatant
Dilution Range:FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Formulation:0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol:CHD1L
Gene ID:9557
Uniprot ID:CHD1L_HUMAN
Function ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin.
Protein Name Chromodomain-Helicase-Dna-Binding Protein 1-Like
Amplified In Liver Cancer Protein 1
Database Links Reactome: R-HSA-5696395
Reactome: R-HSA-5696400
Cellular Localisation Nucleus
Chromosome
Localizes At Sites Of Dna Damage
Recruited By Histones H2b And H3 Poly-Adp-Ribosylated On 'Ser-6' And 'Ser-10'
Respectively (H2bs6adpr And H3s10adpr) By Parp1 Or Parp2
Alternative Antibody Names Anti-Chromodomain-Helicase-Dna-Binding Protein 1-Like antibody
Anti-Amplified In Liver Cancer Protein 1 antibody
Anti-CHD1L antibody
Anti-ALC1 antibody

Information sourced from Uniprot.org