Anti-Recombinant-CDKN2A/p16INK4a antibody [RM1W29] (STJA0024607)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Cyclin-Dependent Kinase Inhibitor 2a for use in IP and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1W29 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IP: 1:20 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CDKN2A |
| Gene ID | 1029 |
| Uniprot ID | CDN2A_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation seems to increase interaction with CDK4. |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 2aCyclin-Dependent Kinase 4 Inhibitor ACdk4iMultiple Tumor Suppressor 1Mts-1P16-Ink4aP16-Ink4P16ink4a |
| Database Links | Reactome: R-HSA-111471Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-3108214Reactome: R-HSA-3232118Reactome: R-HSA-6804757Reactome: R-HSA-69541Reactome: R-HSA-8941858Reactome: R-HSA-9645722Reactome: R-HSA-9646303Reactome: R-HSA-9646304Reactome: R-HSA-9759194Reactome: R-HSA-2559582Reactome: R-HSA-69231Reactome: R-HSA-8853884Reactome: R-HSA-9630791Reactome: R-HSA-9630794Reactome: R-HSA-9632697Reactome: R-HSA-9632700Reactome: R-HSA-9825892 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 2a antibodyAnti-Cyclin-Dependent Kinase 4 Inhibitor A antibodyAnti-Cdk4i antibodyAnti-Multiple Tumor Suppressor 1 antibodyAnti-Mts-1 antibodyAnti-P16-Ink4a antibodyAnti-P16-Ink4 antibodyAnti-P16ink4a antibodyAnti-CDKN2A antibodyAnti-CDKN2 antibodyAnti-MTS1 antibody |
Information sourced from Uniprot.org