Anti-Recombinant-CD349/FZD9 antibody [RM1C60] (STJA0022856)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Frizzled-9 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1C60 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | FZD9 |
| Gene ID | 8326 |
| Uniprot ID | FZD9_HUMAN |
Additional Info
| Post Translational Modifications | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Function | Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling. |
| Protein Name | Frizzled-9Fz-9Hfz9Fze6Cd Antigen Cd349 |
| Database Links | Reactome: R-HSA-373080 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRelocalizes Dvl1 To The Cell Membrane Leading To Phosphorylation Of Dvl1 And Axin1 Relocalization To The Cell Membrane |
| Alternative Antibody Names | Anti-Frizzled-9 antibodyAnti-Fz-9 antibodyAnti-Hfz9 antibodyAnti-Fze6 antibodyAnti-Cd Antigen Cd349 antibodyAnti-FZD9 antibodyAnti-FZD3 antibody |
Information sourced from Uniprot.org