Anti-Recombinant-CASP10 antibody [RM2J53] (STJA0025819)

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STJA0025819
£309.50 - £472.50
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Host: Rabbit
Applications: IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Caspase-10 is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2J53
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: CASP10
Gene ID: 843
Uniprot ID: CASPA_HUMAN
Post Translational Modifications Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive.
Protein Name Caspase-10
Casp-10
Apoptotic Protease Mch-4
Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2
Flice2
Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12
Database Links Reactome: R-HSA-6803207
Reactome: R-HSA-75157
Reactome: R-HSA-75158
Reactome: R-HSA-933543
Alternative Antibody Names Anti-Caspase-10 antibody
Anti-Casp-10 antibody
Anti-Apoptotic Protease Mch-4 antibody
Anti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibody
Anti-Flice2 antibody
Anti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibody
Anti-CASP10 antibody
Anti-MCH4 antibody

Information sourced from Uniprot.org