Anti-Recombinant-CAPN1 antibody [RM1L09] (STJA0023597)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Calpain-1 Catalytic Subunit for use in FC, IF, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1L09 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CAPN1 |
| Gene ID | 823 |
| Uniprot ID | CAN1_HUMAN |
Additional Info
| Post Translational Modifications | Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms. |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. Cleaves and activates caspase-7 (CASP7). |
| Protein Name | Calpain-1 Catalytic SubunitCalcium-Activated Neutral Proteinase 1Canp 1Calpain Mu-TypeCalpain-1 Large SubunitCell Proliferation-Inducing Gene 30 ProteinMicromolar-CalpainMucanp |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-6798695Reactome: R-HSA-6809371Reactome: R-HSA-8862803 |
| Cellular Localisation | CytoplasmCell MembraneTranslocates To The Plasma Membrane Upon Ca(2+) BindingIn Granular Keratinocytes And In Lower CorneocytesColocalizes With Flg And Flg2 |
| Alternative Antibody Names | Anti-Calpain-1 Catalytic Subunit antibodyAnti-Calcium-Activated Neutral Proteinase 1 antibodyAnti-Canp 1 antibodyAnti-Calpain Mu-Type antibodyAnti-Calpain-1 Large Subunit antibodyAnti-Cell Proliferation-Inducing Gene 30 Protein antibodyAnti-Micromolar-Calpain antibodyAnti-Mucanp antibodyAnti-CAPN1 antibodyAnti-CANPL1 antibodyAnti-PIG30 antibody |
Information sourced from Uniprot.org