| Host: | Rabbit |
| Applications: | IF/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Myc Proto-Oncogene Protein is suitable for use in Immunofluorescence, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM1H66 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | IF: 1:50-1:200 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Function | Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CACGATG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. |
| Protein Name | Myc Proto-Oncogene ProteinClass E Basic Helix-Loop-Helix Protein 39Bhlhe39Proto-Oncogene C-MycTranscription Factor P64 |
| Database Links | Reactome: R-HSA-1362277Reactome: R-HSA-201556Reactome: R-HSA-2122947Reactome: R-HSA-2173796Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-4411364Reactome: R-HSA-5687128Reactome: R-HSA-5689880Reactome: R-HSA-6785807Reactome: R-HSA-69202Reactome: R-HSA-69656Reactome: R-HSA-8866911Reactome: R-HSA-8951430Reactome: R-HSA-9018519Reactome: R-HSA-9616222Reactome: R-HSA-9818749 |
| Cellular Localisation | NucleusNucleoplasmNucleolusCytoplasmLocalization To The Nucleolus Is Dependent On Heatr1 |
| Alternative Antibody Names | Anti-Myc Proto-Oncogene Protein antibodyAnti-Class E Basic Helix-Loop-Helix Protein 39 antibodyAnti-Bhlhe39 antibodyAnti-Proto-Oncogene C-Myc antibodyAnti-Transcription Factor P64 antibodyAnti-MYC antibodyAnti-BHLHE39 antibody |
Information sourced from Uniprot.org