Anti-Recombinant-BAZ1B antibody [RM2Q46] (STJA0026406)

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STJA0026406
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Host: Rabbit
Applications: FC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Tyrosine-Protein Kinase Baz1b is suitable for use in Flow Cytometry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2Q46
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: BAZ1B
Gene ID: 9031
Uniprot ID: BAZ1B_HUMAN
Function Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication.
Protein Name Tyrosine-Protein Kinase Baz1b
Bromodomain Adjacent To Zinc Finger Domain Protein 1b
Williams Syndrome Transcription Factor
Williams-Beuren Syndrome Chromosomal Region 10 Protein
Williams-Beuren Syndrome Chromosomal Region 9 Protein
Hwalp2
Database Links Reactome: R-HSA-5250924
Reactome: R-HSA-5693565
Cellular Localisation Nucleus
Accumulates In Pericentromeric Heterochromatin During Replication
Co-Localizes With Pcna At Replication Foci During S Phase
Co-Localizes With Smarca5/Snf2h At Replication Foci During Late-S Phase
Also Localizes To Replication Foci Independently Of Smarca5/Snf2h And Pcna
Localizes To Sites Of Dna Damage
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Baz1b antibody
Anti-Bromodomain Adjacent To Zinc Finger Domain Protein 1b antibody
Anti-Williams Syndrome Transcription Factor antibody
Anti-Williams-Beuren Syndrome Chromosomal Region 10 Protein antibody
Anti-Williams-Beuren Syndrome Chromosomal Region 9 Protein antibody
Anti-Hwalp2 antibody
Anti-BAZ1B antibody
Anti-WBSC10 antibody
Anti-WBSCR10 antibody
Anti-WBSCR9 antibody
Anti-WSTF antibody

Information sourced from Uniprot.org