Anti-Recombinant-BAX antibody [RM2D11] (STJA0025282)

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STJA0025282
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Host: Rabbit
Applications: IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Apoptosis Regulator Bax is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2D11
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: BAX
Gene ID: 581
Uniprot ID: BAX_HUMAN
Post Translational Modifications Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12.
Function Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Protein Name Apoptosis Regulator Bax
Bcl-2-Like Protein 4
Bcl2-L-4
Database Links Reactome: R-HSA-111457
Reactome: R-HSA-114294
Reactome: R-HSA-5620971
Reactome: R-HSA-6803204
Reactome: R-HSA-6804114
Reactome: R-HSA-8878166
Reactome: R-HSA-9603505
Cellular Localisation Isoform Alpha: Mitochondrion Outer Membrane
Single-Pass Membrane Protein
Cytoplasm
Nucleus
Colocalizes With 14-3-3 Proteins In The Cytoplasm
Under Stress Conditions
Undergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion Membrane
Upon Sendai Virus Infection
Recruited To The Mitochondrion Through Interaction With Irf3
Isoform Beta: Cytoplasm
Isoform Gamma: Cytoplasm
Isoform Delta: Cytoplasm
Alternative Antibody Names Anti-Apoptosis Regulator Bax antibody
Anti-Bcl-2-Like Protein 4 antibody
Anti-Bcl2-L-4 antibody
Anti-BAX antibody
Anti-BCL2L4 antibody

Information sourced from Uniprot.org