| Short Description : | Rabbit monoclonal Recombinant-5-Azacytidine-Induced Protein 2 (282-387) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4209RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AZI2 |
| Gene ID: | 64343 |
| Uniprot ID: | AZI2_HUMAN |
| Immunogen Region: | 282-387 |
| Immunogen Sequence: | YTRHPPLLPNGKALCHTTSS PLPGDVKVLSEKAILQSWTD NERSIPNDGTCFQEHSSYGR NSLEDNSWVFPSPPKSSETA FGETKTKTLPLPNLPPLHYL DQHNQN |
| Specificity: | Recombinant protein containing a sequence corresponding to amino acids 282-387 of human AZI2 (NP_071906.1). |
| Tissue Specificity | Widely expressed. Abundant expression seen in the pancreas and testis. |
| Post Translational Modifications | Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation. |
| Function | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. |
| Protein Name | 5-Azacytidine-Induced Protein 2Nf-Kappa-B-Activating Kinase-Associated Protein 1Nak-Associated Protein 1Nap1Tilp |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-5-Azacytidine-Induced Protein 2 antibodyAnti-Nf-Kappa-B-Activating Kinase-Associated Protein 1 antibodyAnti-Nak-Associated Protein 1 antibodyAnti-Nap1 antibodyAnti-Tilp antibodyAnti-AZI2 antibodyAnti-NAP1 antibodyAnti-TBKBP2 antibody |
Information sourced from Uniprot.org
