| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Protein Name | Annexin A2Annexin IiAnnexin-2Calpactin I Heavy ChainCalpactin-1 Heavy ChainChromobindin-8Lipocortin IiPlacental Anticoagulant Protein IvPap-IvProtein IP36 |
| Database Links | Reactome: R-HSA-445355Reactome: R-HSA-6798695Reactome: R-HSA-75205Reactome: R-HSA-8950505 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMelanosomeIn The Lamina Beneath The Plasma MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvTranslocated From The Cytoplasm To The Cell Surface Through A Golgi-Independent Mechanism |
| Alternative Antibody Names | Anti-Annexin A2 antibodyAnti-Annexin Ii antibodyAnti-Annexin-2 antibodyAnti-Calpactin I Heavy Chain antibodyAnti-Calpactin-1 Heavy Chain antibodyAnti-Chromobindin-8 antibodyAnti-Lipocortin Ii antibodyAnti-Placental Anticoagulant Protein Iv antibodyAnti-Pap-Iv antibodyAnti-Protein I antibodyAnti-P36 antibodyAnti-ANXA2 antibodyAnti-ANX2 antibodyAnti-ANX2L4 antibodyAnti-CAL1H antibodyAnti-LPC2D antibody |
Information sourced from Uniprot.org
