| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000IHC-P:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBPJ |
| Gene ID: | 3516 |
| Uniprot ID: | SUH_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBPJK (Q06330). |
| Immunogen Sequence: | CAFIGIGNSDQEMQQLNLEG KNYCTAKTLYISDSDKRKHF MLSVKMFYGNSDDIGVFLSK RIKVISKPSKKKQSLKNADL CIASGTKVALFNRLRSQTVS T |
| Function | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits. |
| Protein Name | Recombining Binding Protein Suppressor Of HairlessCbf-1J Kappa-Recombination Signal-Binding ProteinRbp-J KappaRbp-JRbp-JkRenal Carcinoma Antigen Ny-Ren-30 |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2197563Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-350054Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9793380Reactome: R-HSA-9824272 |
| Cellular Localisation | NucleusCytoplasmMainly NuclearUpon Interaction With Rita/C12orf52Translocates To The CytoplasmDown-Regulating The Notch Signaling Pathway |
| Alternative Antibody Names | Anti-Recombining Binding Protein Suppressor Of Hairless antibodyAnti-Cbf-1 antibodyAnti-J Kappa-Recombination Signal-Binding Protein antibodyAnti-Rbp-J Kappa antibodyAnti-Rbp-J antibodyAnti-Rbp-Jk antibodyAnti-Renal Carcinoma Antigen Ny-Ren-30 antibodyAnti-RBPJ antibodyAnti-IGKJRB antibodyAnti-IGKJRB1 antibodyAnti-RBPJK antibodyAnti-RBPSUH antibody |
Information sourced from Uniprot.org