| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RBMX (1-95) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RBMX |
| Gene ID: |
27316 |
| Uniprot ID: |
RBMX_HUMAN |
| Immunogen Region: |
1-95 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human RBMX/hnRNP G (NP_002130.2). |
| Immunogen Sequence: |
MVEADRPGKLFIGGLNTETN EKALEAVFGKYGRIVEVLLM KDRETNKSRGFAFVTFESPA DAKDAARDMNGKSLDGKAIK VEQATKPSFESGRRG |
| Tissue Specificity | Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level). |
| Post Translational Modifications | O-glycosylated. Arg-185 is dimethylated, probably to asymmetric dimethylarginine. Cleavage of initiator Met is partial. If Met-1 is not removed, it is acetylated. If it is removed, Val-2 is acetylated. |
| Function | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter.may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion.acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CCA/C-rich RNA sequence motifs localized in a single-stranded conformation.probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways.promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. |
| Protein Name | Rna-Binding Motif Protein - X ChromosomeGlycoprotein P43Heterogeneous Nuclear Ribonucleoprotein GHnrnp G Cleaved Into - Rna-Binding Motif Protein - X Chromosome - N-Terminally Processed |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-9013418Reactome: R-HSA-9013422Reactome: R-HSA-9696264Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | NucleusComponent Of RibonucleosomesLocalizes In Numerous Small Granules In The Nucleus |
| Alternative Antibody Names | Anti-Rna-Binding Motif Protein - X Chromosome antibodyAnti-Glycoprotein P43 antibodyAnti-Heterogeneous Nuclear Ribonucleoprotein G antibodyAnti-Hnrnp G Cleaved Into - Rna-Binding Motif Protein - X Chromosome - N-Terminally Processed antibodyAnti-RBMX antibodyAnti-HNRPG antibodyAnti-RBMXP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
