Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | RBMX |
Gene ID: | 27316 |
Uniprot ID: | RBMX_HUMAN |
Immunogen Region: | 1-95 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human RBMX/hnRNP G (NP_002130.2). |
Immunogen Sequence: | MVEADRPGKLFIGGLNTETN EKALEAVFGKYGRIVEVLLM KDRETNKSRGFAFVTFESPA DAKDAARDMNGKSLDGKAIK VEQATKPSFESGRRG |
Tissue Specificity | Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level). |
Post Translational Modifications | O-glycosylated. Arg-185 is dimethylated, probably to asymmetric dimethylarginine. Cleavage of initiator Met is partial. If Met-1 is not removed, it is acetylated. If it is removed, Val-2 is acetylated. |
Function | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter.may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion.acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CCA/C-rich RNA sequence motifs localized in a single-stranded conformation.probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways.promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. |
Protein Name | Rna-Binding Motif Protein - X Chromosome Glycoprotein P43 Heterogeneous Nuclear Ribonucleoprotein G Hnrnp G Cleaved Into - Rna-Binding Motif Protein - X Chromosome - N-Terminally Processed |
Database Links | Reactome: R-HSA-72163 Reactome: R-HSA-72203 Reactome: R-HSA-9013418 Reactome: R-HSA-9013422 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 |
Cellular Localisation | Nucleus Component Of Ribonucleosomes Localizes In Numerous Small Granules In The Nucleus |
Alternative Antibody Names | Anti-Rna-Binding Motif Protein - X Chromosome antibody Anti-Glycoprotein P43 antibody Anti-Heterogeneous Nuclear Ribonucleoprotein G antibody Anti-Hnrnp G Cleaved Into - Rna-Binding Motif Protein - X Chromosome - N-Terminally Processed antibody Anti-RBMX antibody Anti-HNRPG antibody Anti-RBMXP1 antibody |
Information sourced from Uniprot.org