Anti-RBM15B antibody (540-720) (STJ111915)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RBM15B (540-720) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RBM15B |
| Gene ID | 29890 |
| Uniprot ID | RB15B_HUMAN |
| Immunogen Region | 540-720 |
| Immunogen Sequence | DRDRTFLEGDWTSPSKSSDR RNSLEGYSRSVRSRSGERWG ADGDRGLPKPWEERRKRRSL SSDRGRTTHSPYEERSRTKG SGQQSERGSDRTPERSRKEN HSSEGTKESSSNSLSNSRHG AEERGHHHHHHEAADSSHGK KARDSERNHRTTEAEPKPLE EPKHETKKLKNLSEYAQTLQ L |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of human RBM15B (NP_037418.3). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1. |
| Protein Name | Putative Rna-Binding Protein 15bOne-Twenty Two Protein 3Hsott3Huott3Rna-Binding Motif Protein 15b |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmNucleus SpeckleNucleus EnvelopeColocalizes With Bmlf1 In The NucleusLocalized In The Nucleoplasm With A Granular Staining Pattern And Excluded From The Nucleoli |
| Alternative Antibody Names | Anti-Putative Rna-Binding Protein 15b antibodyAnti-One-Twenty Two Protein 3 antibodyAnti-Hsott3 antibodyAnti-Huott3 antibodyAnti-Rna-Binding Motif Protein 15b antibodyAnti-RBM15B antibodyAnti-OTT3 antibody |
Information sourced from Uniprot.org