| Short Description : | Rabbit polyclonal RBM11 (1-281) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBM11 |
| Gene ID: | 54033 |
| Uniprot ID: | RBM11_HUMAN |
| Immunogen Region: | 1-281 |
| Immunogen Sequence: | MFPAQEEADRTVFVGNLEAR VREEILYELFLQAGPLTKVT ICKDREGKPKSFGFVCFKHP ESVSYAIALLNGIRLYGRPI NVQYRFGSSRSSEPANQSFE SCVKINSHNYRNEEMLVGRS SFPMQYFPINNTSLPQEYFL FQKMQWHVYNPVLQLPYYEM TAPLPNSASVSSSLNHVPDL EAGPSSYKWTHQQPSDSDLY QMTAPLPNSASVSSSLNHVP DLEAGPSSYKWTHQQPSDS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human RBM11 (NP_658983.3). |
| Tissue Specificity | Expressed in brain, hippocampus, prefrontal cortex, cerebellum, spinal cord, testis, mammary gland, spleen and kidney. Also expressed in fetal brain. |
| Function | Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1. |
| Protein Name | Splicing Regulator Rbm11Rna-Binding Motif Protein 11 |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmNucleus SpeckleEnriched In Srsf2-Containing Splicing SpecklesShuttles Between Nucleoplasm And Speckles |
| Alternative Antibody Names | Anti-Splicing Regulator Rbm11 antibodyAnti-Rna-Binding Motif Protein 11 antibodyAnti-RBM11 antibody |
Information sourced from Uniprot.org
