| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RBBP6 (1-118) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RBBP6 |
| Gene ID: |
5930 |
| Uniprot ID: |
RBBP6_HUMAN |
| Immunogen Region: |
1-118 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RBBP6 (NP_116015.2). |
| Immunogen Sequence: |
MSCVHYKFSSKLNYDTVTFD GLHISLCDLKKQIMGREKLK AADCDLQITNAQTKEEYTDD NALIPKNSSVIVRRIPIGGV KSTSKTYVISRTEPAMATTK AVCKNTISHFFYTLLLPL |
| Tissue Specificity | Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. |
| Post Translational Modifications | Phosphorylated by NEK6. |
| Function | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53.may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication. (Microbial infection) Isoform 1: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rbbp6Proliferation Potential-Related ProteinProtein P2p-RRing-Type E3 Ubiquitin Transferase Rbbp6Retinoblastoma-Binding Q Protein 1Rbq-1Retinoblastoma-Binding Protein 6P53-Associated Cellular Protein Of Testis |
| Database Links | Reactome: R-HSA-9013422Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusNucleolusChromosomeCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes With Mitotic ChromosomesColocalizes With Nek6 In The Centrosome |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rbbp6 antibodyAnti-Proliferation Potential-Related Protein antibodyAnti-Protein P2p-R antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rbbp6 antibodyAnti-Retinoblastoma-Binding Q Protein 1 antibodyAnti-Rbq-1 antibodyAnti-Retinoblastoma-Binding Protein 6 antibodyAnti-P53-Associated Cellular Protein Of Testis antibodyAnti-RBBP6 antibodyAnti-P2PR antibodyAnti-PACT antibodyAnti-RBQ1 antibodyAnti-My038 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
