| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RASSF1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 0.02% NaN3 |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RASSF5 |
| Gene ID: | 83593 |
| Uniprot ID: | RASF5_HUMAN |
| Specificity: | Reacts with residues located in the RA domain of human, mouse and rat NORE1 protein. |
| Immunogen: | Synthetic peptide corresponding to amino acids from the RA domain of human NORE1 |
| Function | Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. |
| Protein Name | Ras Association Domain-Containing Protein 5 New Ras Effector 1 Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues Rapl |
| Cellular Localisation | Cytoplasm Cytoskeleton Isoform 2 Is Mainly Located In The Perinuclear Region Of Unstimulated Primary T-Cells Upon Stimulation Translocates To The Leading Edge And Colocalizes With Itgal/Lfa-1 In The Peripheral Zone Of The Immunological Synapse Isoform 2 Is Localized To Growing Microtubules In Vascular Endothelial Cells And Is Dissociated From Microtubules By Activated Rap1a |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 5 antibody Anti-New Ras Effector 1 antibody Anti-Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues antibody Anti-Rapl antibody Anti-RASSF5 antibody Anti-NORE1 antibody Anti-RAPL antibody |
Information sourced from Uniprot.org