| Host: |
Rabbit |
| Applications: |
WB/IF/ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ras association domain-containing protein 5 (234-284 aa) is suitable for use in Western Blot, Immunofluorescence, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IF ICC 1:50-200ELISA 1:2000-20000IHC-P 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RASSF5 |
| Gene ID: |
83593 |
| Uniprot ID: |
RASF5_HUMAN |
| Immunogen Region: |
234-284 aa |
| Specificity: |
This antibody detects endogenous levels of RASF5 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human RASF5 at the amino acid range 234-284 |
| Function | Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. |
| Protein Name | Ras Association Domain-Containing Protein 5New Ras Effector 1Regulator For Cell Adhesion And Polarization Enriched In Lymphoid TissuesRapl |
| Cellular Localisation | CytoplasmCytoskeletonIsoform 2 Is Mainly Located In The Perinuclear Region Of Unstimulated Primary T-CellsUpon Stimulation Translocates To The Leading Edge And Colocalizes With Itgal/Lfa-1 In The Peripheral Zone Of The Immunological SynapseIsoform 2 Is Localized To Growing Microtubules In Vascular Endothelial Cells And Is Dissociated From Microtubules By Activated Rap1a |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 5 antibodyAnti-New Ras Effector 1 antibodyAnti-Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues antibodyAnti-Rapl antibodyAnti-RASSF5 antibodyAnti-NORE1 antibodyAnti-RAPL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
