Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Monoclonal |
Clone ID : | S4103RM |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | RASSF2 |
Gene ID: | 9770 |
Uniprot ID: | RASF2_HUMAN |
Immunogen Region: | 227-326 |
Specificity: | A synthetic peptide corresponding to a sequence within amino acids 227-326 of human RASSF2 (P50749). |
Immunogen Sequence: | HTSGEKQKLKATDYPLIARI LQGPCEQISKVFLMEKDQVE EVTYDVAQYIKFEMPVLKSF IQKLQEEEDREVKKLMRKYT VLRLMIRQRLEEIAETPATI |
Tissue Specificity | Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines. |
Post Translational Modifications | Phosphorylated by STK3/MST2 and STK4/MST1. |
Function | Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. |
Protein Name | Ras Association Domain-Containing Protein 2 |
Cellular Localisation | NucleusCytoplasmChromosomeCentromereKinetochoreTranslocates To The Cytoplasm In The Presence Of Stk3/Mst2 And Stk4/Mst1 |
Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 2 antibodyAnti-RASSF2 antibodyAnti-CENP-34 antibodyAnti-KIAA0168 antibody |
Information sourced from Uniprot.org