Anti-RASIP1 antibody (620-700 aa) (STJ191265)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 620-700
General Information
| Short Description | Rabbit polyclonal anti-Ras-interacting protein 1 (620-700 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASIP1 |
| Gene ID | 54922 |
| Uniprot ID | RAIN_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 620-700 |
| Immunogen Region | 620-700 aa |
| Specificity | RAIN Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. |
| Protein Name | Ras-Interacting Protein 1Rain |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionGolgi ApparatusGolgi StackAssociated With Perinuclear VesiclesIs Recruited To Golgi Stacks By Activated Hras |
| Alternative Antibody Names | Anti-Ras-Interacting Protein 1 antibodyAnti-Rain antibodyAnti-RASIP1 antibody |
Information sourced from Uniprot.org