| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RASA4 |
| Gene ID: | 10156 |
| Uniprot ID: | RASL2_HUMAN |
| Immunogen Region: | 60-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human RASA4 (NP_008920.5). |
| Immunogen Sequence: | HLPPTFHAVAFYVMDEDALS RDDVIGKVCLTRDTIASHPK GFSGWAHLTEVDPDEEVQGE IHLRLEVWPGARACRLRCSV LEARDLAPKDRNGTSDPFVR VRYKGRTRETSIVKKSCYPR WNETFEFELQEGAMEALCVE AWDWDLVSRNDFLGKVVIDV QRLRVVQQEEGWFRLQPDQS KSRRHDEGNLGSLQLEVRLR DETVLPSSYYQPLVHLLCHE VKLGMQGPGQL |
| Tissue Specificity | Widely expressed. |
| Function | Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. |
| Protein Name | Ras Gtpase-Activating Protein 4Calcium-Promoted Ras InactivatorRas P21 Protein Activator 4Rasgap-Activating-Like Protein 2 |
| Database Links | Reactome: R-HSA-5658442 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinLocalized To The Cytosol As A Result Of Its Lack Of Phosphoinositide Binding ActivityUpon Agonist-Stimulated Calcium MobilizationUtilizes The C2a And C2b Domains To Associate With The Plasma Membrane |
| Alternative Antibody Names | Anti-Ras Gtpase-Activating Protein 4 antibodyAnti-Calcium-Promoted Ras Inactivator antibodyAnti-Ras P21 Protein Activator 4 antibodyAnti-Rasgap-Activating-Like Protein 2 antibodyAnti-RASA4 antibodyAnti-CAPRI antibodyAnti-GAPL antibodyAnti-KIAA0538 antibody |
Information sourced from Uniprot.org