| Tissue Specificity | In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). |
| Post Translational Modifications | The N-terminus is blocked. Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity. |
| Function | Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.this stimulation may be further increased in the presence of NCK1. |
| Protein Name | Ras Gtpase-Activating Protein 1GapGtpase-Activating ProteinRasgapRas P21 Protein ActivatorP120gap |
| Database Links | Reactome: R-HSA-186763Reactome: R-HSA-3928662Reactome: R-HSA-5218921Reactome: R-HSA-5658442Reactome: R-HSA-8849471 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ras Gtpase-Activating Protein 1 antibodyAnti-Gap antibodyAnti-Gtpase-Activating Protein antibodyAnti-Rasgap antibodyAnti-Ras P21 Protein Activator antibodyAnti-P120gap antibodyAnti-RASA1 antibodyAnti-GAP antibodyAnti-RASA antibody |
Information sourced from Uniprot.org
