| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ran-binding protein 3 (421-471 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RANBP3 |
| Gene ID: |
8498 |
| Uniprot ID: |
RANB3_HUMAN |
| Immunogen Region: |
421-471 aa |
| Specificity: |
This antibody detects endogenous levels of RANB3 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human RANB3 at the amino acid range 421-471 |
| Post Translational Modifications | Phosphorylation at Ser-126 promotes its import into the nucleus. |
| Function | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. |
| Protein Name | Ran-Binding Protein 3Ranbp3 |
| Cellular Localisation | CytoplasmNucleusNuclear Import Is Promoted By Phosphorylation At Ser-126 And Is Dependent On Kpna4 |
| Alternative Antibody Names | Anti-Ran-Binding Protein 3 antibodyAnti-Ranbp3 antibodyAnti-RANBP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
