| Short Description : | Rabbit polyclonal RAMP2 (1-145) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAMP2 |
| Gene ID: | 10266 |
| Uniprot ID: | RAMP2_HUMAN |
| Immunogen Region: | 1-145 |
| Immunogen Sequence: | MASLRVERAGGPRLPRTRVG RPAALRLLLLLGAVLNPHEA LAQPLPTTGTPGSEGGTVKN YETAVQFCWNHYKDQMDPIE KDWCDWAMISRPYSTLRDCL EHFAELFDLGFPNPLAERII FETHQIHFANCSLVQPTFSD PPEDV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human RAMP2 (NP_005845.2). |
| Tissue Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. |
| Function | Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP. |
| Protein Name | Receptor Activity-Modifying Protein 2Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2Crlr Activity-Modifying Protein 2 |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor Activity-Modifying Protein 2 antibodyAnti-Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2 antibodyAnti-Crlr Activity-Modifying Protein 2 antibodyAnti-RAMP2 antibody |
Information sourced from Uniprot.org
