| Tissue Specificity | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
| Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. |
| Protein Name | Death Domain-Containing Protein CraddCaspase And Rip Adapter With Death DomainRip-Associated Protein With A Death Domain |
| Database Links | Reactome: R-HSA-6803207 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Death Domain-Containing Protein Cradd antibodyAnti-Caspase And Rip Adapter With Death Domain antibodyAnti-Rip-Associated Protein With A Death Domain antibodyAnti-CRADD antibodyAnti-RAIDD antibody |
Information sourced from Uniprot.org
