| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Rad23A (1-363) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAD23A |
| Gene ID: |
5886 |
| Uniprot ID: |
RD23A_HUMAN |
| Immunogen Region: |
1-363 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-363 of human Rad23A (NP_005044.1). |
| Immunogen Sequence: |
MAVTITLKTLQQQTFKIRME PDETVKVLKEKIEAEKGRDA FPVAGQKLIYAGKILSDDVP IRDYRIDEKNFVVVMVTKTK AGQGTSAPPEASPTAAPESS TSFPPAPTSGMSHPPPAARE DKSPSEESAPTTSPESVSGS VPSSGSSGREEDAASTLVTG SEYETMLTEIMSMGYERERV VAALRASYNNPHRAVEYLLT GIPGSPEPEHGSVQESQVSE QPATEAAGENPLEFLRDQP |
| Function | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. |
| Protein Name | Uv Excision Repair Protein Rad23 Homolog AHr23aHhr23a |
| Database Links | Reactome: R-HSA-5689877Reactome: R-HSA-5696394Reactome: R-HSA-5696395 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Uv Excision Repair Protein Rad23 Homolog A antibodyAnti-Hr23a antibodyAnti-Hhr23a antibodyAnti-RAD23A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
