Anti-RAB6B antibody (C-Term) (STJ13100309)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from c-terminal region of human Ras-related protein Rab-6B (RAB6B) conjugated to an immunogenic carrier protein has been used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-RAB6B (C-Term) for use in IHC and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. Use at a dilution of 1:300 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | RAB6B |
| Gene ID | 51560 |
| Uniprot ID | RAB6B_HUMAN |
| Immunogen | A synthetic peptide from c-terminal region of human Ras-related protein Rab-6B (RAB6B) conjugated to an immunogenic carrier protein has been used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for RAB6B. |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Recruits VPS13B to the Golgi membrane. Regulates the compacted morphology of the Golgi. Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells. Plays a role in neuron projection development. |
| Protein Name | Ras-Related Protein Rab-6b |
| Database Links | Reactome: R-HSA-6811436Reactome: R-HSA-6811440Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorEndoplasmic Reticulum-Golgi Intermediate CompartmentCytoplasmic VesicleColocalizes With Bicd1 At Vesicular Structures That Align Along Microtubules |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-6b antibodyAnti-RAB6B antibody |
Information sourced from Uniprot.org