| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Recruits VPS13B to the Golgi membrane. Regulates the compacted morphology of the Golgi. Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells. Plays a role in neuron projection development. |
| Protein Name | Ras-Related Protein Rab-6b |
| Database Links | Reactome: R-HSA-6811436Reactome: R-HSA-6811440Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorEndoplasmic Reticulum-Golgi Intermediate CompartmentCytoplasmic VesicleColocalizes With Bicd1 At Vesicular Structures That Align Along Microtubules |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-6b antibodyAnti-RAB6B antibody |
Information sourced from Uniprot.org
