| Short Description : | Rabbit polyclonal Ras-Related Protein Rab-5c (1-216) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAB5C |
| Gene ID: | 5878 |
| Uniprot ID: | RAB5C_HUMAN |
| Immunogen Region: | 1-216 |
| Immunogen Sequence: | MAGRGGAARPNGPAAGNKIC QFKLVLLGESAVGKSSLVLR FVKGQFHEYQESTIGAAFLT QTVCLDDTTVKFEIWDTAGQ ERYHSLAPMYYRGAQAAIVV YDITNTDTFARAKNWVKELQ RQASPNIVIALAGNKADLAS KRAVEFQEAQAYADDNSLLF METSAKTAMNVNEIFMAIAK KLPKNEPQNATGAPGRNRGV DLQENNPASRSQCCSN |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human RAB5C (NP_958842.1). |
| Post Translational Modifications | Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. |
| Protein Name | Ras-Related Protein Rab-5cL1880Rab5l |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6798695Reactome: R-HSA-8854214Reactome: R-HSA-8856828Reactome: R-HSA-8873719Reactome: R-HSA-8876198Reactome: R-HSA-9820960 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideEarly Endosome MembraneMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-5c antibodyAnti-L1880 antibodyAnti-Rab5l antibodyAnti-RAB5C antibodyAnti-RABL antibody |
Information sourced from Uniprot.org
